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Mechanisms of Inhibition of Various Cellular DNA and RNA Polymerases by Several Flavonoids

1 Oct 1990

Abstract excerpt

Four flavonoids (i.e., baicalein, quercetin, quercetagetin, and myricetin), known to be inhibitors of HIV-reverse transcriptase, have been shown to be more or less inhibitory to the activities of various cellular DNA and RNA polymerases. The degree of the inhibition varied depending on the combination of the flavonoid and the enzyme species: baicalein was moderately inhibitory to DNA polymerase gamma and E. coli...

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PMID: 2292590
DOI: 10.1093/oxfordjournals.jbchem.a123251

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