Article
Paramutation in Drosophila linked to emergence of a piRNA-producing locus.
Nature - 4 Oct 2012
de Vanssay Augustin, Bougé Anne-Laure, Boivin Antoine, Hermant Catherine, Teysset Laure, Delmarre Valérie, Antoniewski Christophe, Ronsseray Stéphane
Abstract excerpt
A paramutation is an epigenetic interaction between two alleles of a locus, through which one allele induces a heritable modification in the other allele without modifying the DNA sequence. The paramutated allele itself becomes paramutagenic, that is, capable of epigenetically converting a new paramutable allele. Here we describe a case of paramutation in animals showing long-term transmission over generations....
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