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Article

The Role of microRNAs in Helicobacter pylori Pathogenesis and Gastric Carcinogenesis

1 Jan 2012

Abstract excerpt

Gastric carcinogenesis is a multistep process orchestrated by aberrancies in the genetic and epigenetic regulation of oncogenes and tumor suppressor genes. Chronic infection with Helicobacter pylori is the strongest known risk factor for the development of gastric cancer. H. pylori expresses a spectrum of virulence factors that dysregulate host intracellular signaling pathways that lower the threshold for...

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PMID: 22919587
DOI: 10.3389/fcimb.2011.00021

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