Article
Major host factors involved in epithelial cell invasion of Campylobacter jejuni: role of fibronectin, integrin beta1, FAK, Tiam-1, and DOCK180 in activating Rho GTPase Rac1.
Frontiers in cellular and infection microbiology - 1 Jan 2011
Boehm Manja, Krause-Gruszczynska Malgorzata, Rohde Manfred, Tegtmeyer Nicole, Takahashi Seiichiro, Oyarzabal Omar A, Backert Steffen
Abstract excerpt
Host cell entry by the food-borne pathogen Campylobacter jejuni has been reported as one of the primary reasons of tissue damage in infected humans, however, molecular invasion mechanisms and cellular factors involved in this process are widely unclear. Here we used knockout cell lines derived from fibronectin(-/-), integrin beta1(-/-), and focal adhesion kinase (FAK)(-/-) deficient mice and corresponding...
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