Article
Cytoplasmic localization of PML particles in laminopathies.
Histochemistry and cell biology - 1 Jan 2013
Houben F, De Vos W H, Krapels I P C, Coorens M, Kierkels G J J, Kamps M A F, Verstraeten V L R M, Marcelis C L M, van den Wijngaard A, Ramaekers F C S, Broers J L V
Abstract excerpt
There is growing evidence that laminopathies, diseases associated with mutations in the LMNA gene, are caused by a combination of mechanical and gene regulatory distortions. Strikingly, there is a large variability in disease symptoms between individual patients carrying an identical LMNA mutation. This is why classical genetic screens for mutations appear to have limited predictive value for disease development....
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