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Article

Mosaic moles and non-familial biparental moles are not caused by mutations in NLRP7, NLRP2 or C6orf221.

Molecular human reproduction - 1 Dec 2012

Andreasen L, Bolund L, Niemann I, Hansen E S, Sunde L

Abstract excerpt

Hydatidiform moles (HMs) most often occur sporadically and are either diploid androgenetic or triploid. The very rare familial recurrent HMs (FRHMs) have been related to NLRP7 and C6orf221 mutations in the mother. FRHMs are most often diploid with both maternal and paternal origin of the molar genome. We have screened a cohort of 11 women with diploid HMs with biparental contributions to the molar genome with...

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Identifiers

PMID: 22909446
DOI: 10.1093/molehr/gas036

Genes

NLRP7
NLRP2

Provenance

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Mosaic moles and non-familial biparental moles are not caused by mutations in NLRP7, NLRP2 or C6orf221.PMID 22909446Read ↗

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Maternal NLRP7 and C6orf221 variants are not a common risk factor for androgenetic moles, triploidy and recurrent miscarriage.Semantic proximity Read ↗

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The genetics of recurrent hydatidiform moles in China: correlations between NLRP7 mutations, molar genotypes and reproductive outcomes.Semantic proximity Read ↗

No evidence for mutations in NLRP7 and KHDC3L in women with androgenetic hydatidiform moles.Semantic proximity Read ↗

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