Resampling QTL effects in the QTL sign test leads to incongruous sensitivity to variance in effect size.

doi:10.1534/g3.112.003228

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Article

Resampling QTL effects in the QTL sign test leads to incongruous sensitivity to variance in effect size.

G3 (Bethesda, Md.) - 1 Aug 2012

Rice Daniel P, Townsend Jeffrey P

Abstract excerpt

Allelic effects at quantitative trait loci (QTL) between lineages are potentially informative for indicating the action of natural selection. The QTL Sign Test uses the number of + and - alleles observed in a QTL study to infer a history of selection. This test has been constructed to condition on the phenotypic difference between the two lines in question. By applying the test to QTL data simulated under...

Topics

Alleles
Models, Genetic
Phenotype
Quantitative Trait Loci
Quantitative Trait, Heritable
Selection, Genetic

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Identifiers

PMID: 22908039
DOI: 10.1534/g3.112.003228
PMCID: PMC3411246

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