Article
Excess of HLA parental sharing in families with Turner patients.
Clinical genetics - 1 Dec 1990
Cuccia M, Martinetti M, Larizza D, Bolis P F, Severi F
Abstract excerpt
In utero selection processes are probably related to mother-father compatibility as has been reported in abortion-prone couples and in Down syndrome studies. In order to analyse this phenomenon, we investigated families with chromosomal imbalance (Turner syndrome). We chose this model because previous data indicated a high frequency of HLA-A31 and B38 in Turner patients and in their mothers. We report high HLA...
Topics
- Abortion, Habitual
- Antilymphocyte Serum
- Child
- Female
- Gene Frequency
- HLA Antigens
- Humans
- Karyotyping
- Phenotype
- Polymorphism, Genetic
- Pregnancy
- Risk Factors