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Evaluation of unrestricted somatic stem cells as a feeder layer to support undifferentiated embryonic stem cells

7 Aug 2012

Abstract excerpt

The use of unrestricted somatic stem cells (USSCs) holds great promise for future clinical applications. Conventionally, mouse embryonic fibroblasts (MEFs) or other animal-based feeder layers are used to support embryonic stem cell (ESC) growth; the use of such feeder cells increases the risk of retroviral and other pathogenic infection in clinical trials. Implementation of a human-based feeder layer, such as...

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PMID: 22888050
DOI: 10.1002/mrd.22079

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