Article
[Cytogenomic studies of hydatiform moles and gestational choriocarcinoma].
Bulletin du cancer - 1 Sept 2012
Poaty Henriette, Coullin Philippe, Leguern Eric, Dessen Philippe, Valent Alexandre, Afoutou José-Marie, Peko Jean-Félix, Candelier Jean-Jacques, Gombé-Mbalawa Charles, Picard Jean-Yves, Bernheim Alain
Abstract excerpt
The complete hydatidiform mole (CHM), a gestational trophoblastic disease, is usually caused by the development of an androgenic egg whose genome is exclusively paternal. Due to parental imprinting, only trophoblasts develop in the absence of a fetus. CHM are diploid and no abnormal karyotype is observed. It is 46,XX in most cases and less frequently 46,XY. The major complication of this disease is gestational...
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