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The catalytic mechanism of the hotdog-fold enzyme superfamily 4-hydroxybenzoyl-CoA thioesterase from Arthrobacter sp. strain SU.

Biochemistry - 4 Sept 2012

Song Feng, Thoden James B, Zhuang Zhihao, Latham John, Trujillo Michael, Holden Hazel M, Dunaway-Mariano Debra

Abstract excerpt

The hotdog-fold enzyme 4-hydroxybenzoyl-coenzyme A (4-HB-CoA) thioesterase from Arthrobacter sp. strain AU catalyzes the hydrolysis of 4-HB-CoA to form 4-hydroxybenzoate (4-HB) and coenzyme A (CoA) in the final step of the 4-chlorobenzoate dehalogenation pathway. Guided by the published X-ray structures of the liganded enzyme (Thoden, J. B., Zhuang, Z., Dunaway-Mariano, D., and Holden H. M. (2003) J. Biol. Chem....

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PMID: 22873756
DOI: 10.1021/bi301059m
PMCID: PMC4710518

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