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Article

The response to PAK1 inhibitor IPA3 distinguishes between cancer cells with mutations in BRAF and Ras oncogenes.

Oncotarget - 1 Jul 2012

Singhal Ruchi, Kandel Eugene S

Abstract excerpt

While new drugs aimed at BRAF-mutated cancers are entering clinical practice, cells and tumors with activating Ras mutations are relatively resistant to those and quite a few other anti-cancer agents. This inspires the effort to reverse this resistance or to uncover new vulnerabilities in such resistant cancers. IPA3 has been originally identified as a small molecule inhibitor of p21-activated protein kinase 1...

Topics

Cell Line, Tumor
Colonic Neoplasms
Genes, ras
Humans
Melanoma
Mutation
Protein Kinase Inhibitors
Proto-Oncogene Proteins B-raf
p21-Activated Kinases

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Open in PubMed Open full text

Identifiers

PMID: 22869096
DOI: 10.18632/oncotarget.587
PMCID: PMC3443253

Genes

PAK1
BRAF
NRAS
KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-22869096-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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