Article
Proteomic and transcriptomic profiling of Staphylococcus aureus surface LPXTG-proteins: correlation with agr genotypes and adherence phenotypes.
Molecular & cellular proteomics : MCP - 1 Nov 2012
Ythier Mathilde, Resch Grégory, Waridel Patrice, Panchaud Alexandre, Gfeller Aurélie, Majcherczyk Paul, Quadroni Manfredo, Moreillon Philippe
Abstract excerpt
Staphylococcus aureus infections involve numerous adhesins and toxins, which expression depends on complex regulatory networks. Adhesins include a family of surface proteins covalently attached to the peptidoglycan via a conserved LPXTG motif. Here we determined the protein and mRNA expression of LPXTG-proteins of S. aureus Newman in time-course experiments, and their relation to fibrinogen adherence in vitro....
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