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Alkaloids from <i>Pachysandra terminalis</i> Inhibit Breast Cancer Invasion and Have Potential for Development As Antimetastasis Therapeutic Agents

17 Jul 2012

Abstract excerpt

The aim of the present study was to identify potentially useful natural compounds for the development of novel therapeutic agents to inhibit metastasis. A phytochemical investigation of Pachysandra terminalis resulted in the isolation of seven new pregnane alkaloids, terminamines A-G (1-7), and seven known alkaloids (8-14). The structures of 1-7 were elucidated by 1D- and 2D-NMR spectroscopic and mass...

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PMID: 22804108
DOI: 10.1021/np300207c

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