Article
The variable sensitivity of HIV Ag/Ab combination assays in the detection of p24Ag according to genotype could compromise the diagnosis of early HIV infection.
Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology - 1 Oct 2012
Ly Thoai Duong, Plantier Jean Christophe, Leballais Lionel, Gonzalo Sylvie, Lemée Véronique, Laperche Syria
Abstract excerpt
BACKGROUND: In France, HIV infection diagnosis was modified by a decree, published in 2010, that requires the use of HIV Ag/Ab assays able to detect at least 2 IU/ml of p24Ag. This measure raises the concern of the capacity of these assays to equally detect all HIV variants. OBJECTIVES: To assess the performance of HIV Ag/Ab assays for the detection of p24Ag from diverse HIV isolates. STUDY DESIGN: Ten HIV Ag/Ab...
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