Article
A single promoter inversion switches Photorhabdus between pathogenic and mutualistic states.
Science (New York, N.Y.) - 6 Jul 2012
Somvanshi Vishal S, Sloup Rudolph E, Crawford Jason M, Martin Alexander R, Heidt Anthony J, Kim Kwi-suk, Clardy Jon, Ciche Todd A
Abstract excerpt
Microbial populations stochastically generate variants with strikingly different properties, such as virulence or avirulence and antibiotic tolerance or sensitivity. Photorhabdus luminescens bacteria have a variable life history in which they alternate between pathogens to a wide variety of insects and mutualists to their specific host nematodes. Here, we show that the P. luminescens pathogenic variant (P form)...
Topics
- Animals
- Fimbriae Proteins
- Gene Expression Regulation, Bacterial
- Genome, Bacterial
- Intestines
- Moths
- Mutation
- Phenotype
- Photorhabdus
- Promoter Regions, Genetic
- Rhabditoidea
- Sequence Inversion
- Symbiosis