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Article

Multifocal ectopic Purkinje-related premature contractions: a new SCN5A-related cardiac channelopathy.

Journal of the American College of Cardiology - 10 Jul 2012

Laurent Gabriel, Saal Samuel, Amarouch Mohamed Yassine, Béziau Delphine M, Marsman Roos F J, Faivre Laurence, Barc Julien, Dina Christian, Bertaux Geraldine, Barthez Olivier, Thauvin-Robinet Christel, Charron Philippe, Fressart Véronique, Maltret Alice, Villain Elisabeth, Baron Estelle, Mérot Jean, Turpault Rodolphe, Coudière Yves, Charpentier Flavien, Schott Jean-Jacques, Loussouarn Gildas, Wilde Arthur A M, Wolf Jean-Eric, Baró Isabelle, Kyndt Florence, Probst Vincent

Abstract excerpt

OBJECTIVES: The aim of this study was to describe a new familial cardiac phenotype and to elucidate the electrophysiological mechanism responsible for the disease. BACKGROUND: Mutations in several genes encoding ion channels, especially SCN5A, have emerged as the basis for a variety of inherited cardiac arrhythmias. METHODS: Three unrelated families comprising 21 individuals affected by multifocal ectopic...

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Anti-Arrhythmia Agents
Arrhythmias, Cardiac
Cardiomyopathy, Dilated

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Death, Sudden, Cardiac

Electrophysiologic Techniques, Cardiac

Myocardial Contraction

NAV1.5 Voltage-Gated Sodium Channel

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PMID: 22766342
DOI: 10.1016/j.jacc.2012.02.052

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Multifocal ectopic Purkinje-related premature contractions: a new SCN5A-related cardiac channelopathy.PMID 22766342Read ↗

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