Article
Chronic reduction in inhibition reduces receptive field size in mouse auditory cortex.
Proceedings of the National Academy of Sciences of the United States of America - 21 Aug 2012
Seybold Bryan A, Stanco Amelia, Cho Kathleen K A, Potter Gregory B, Kim Carol, Sohal Vikaas S, Rubenstein John L R, Schreiner Christoph E
Abstract excerpt
Inhibitory interneurons regulate the responses of cortical circuits. In auditory cortical areas, inhibition from these neurons narrows spectral tuning and shapes response dynamics. Acute disruptions of inhibition expand spectral receptive fields. However, the effects of long-term perturbations of inhibitory circuitry on auditory cortical responses are unknown. We ablated ~30% of dendrite-targeting cortical...
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