Article
Upregulation of miR-196b confers a poor prognosis in glioblastoma patients via inducing a proliferative phenotype.
PloS one - 1 Jan 2012
Ma Ruimin, Yan Wei, Zhang Guojun, Lv Hong, Liu Zhizhong, Fang Fang, Zhang Wei, Zhang Junxia, Tao Tao, You Yongping, Jiang Tao, Kang Xixiong
Abstract excerpt
PURPOSE: To explore the expression pattern, prognostic value and functional role of miR-196b in glioblastoma (GBM) patients using large cohorts. EXPERIMENTAL DESIGN: MiR-196b expression was measured using the Human v2.0 miRNA Expression BeadChip (Illumina) in 198 frozen glioma tissues. The expression levels of miR-196b were also validated in an independent cohort containing 128 formalin-fixed paraffin-embedded...
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