Article
The wound-healing response and upregulated embryonic mechanisms: brothers-in-arms forever.
Experimental dermatology - 1 Jul 2012
Aller María-Angeles, Blanco-Rivero Javier, Arias Jose-Ignacio, Balfagon Gloria, Arias Jaime
Abstract excerpt
The cutaneous wound-healing reaction occurs in overlapping but inter-related phases, which ultimately result in fibrosis. The pathophysiological mechanisms involved in fibrotic diseases, including organ-related and even systemic diseases, such as systemic sclerosis, could represent the successive systemic upregulation of extraembryonic-like phenotypes, that is, amniotic and vitelline phenotypes. These two...
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