Article
A new development of FG-CC' siRNA blocking interaction of Tim-1 and Tim-4 can enhance DC vaccine against gastric cancer .
Hepato-gastroenterology - 1 Jan 2000
Sun Hua-Wen, Wu Chong, Tan Hai-Yan, Wang Qiu-Shuang
Abstract excerpt
BACKGROUND/AIMS: Dendritic cells (DCs) are professional antigen-presenting cells responsible for initiating of immune response. However, because of immune tolerance, it is difficult to induce long-term tumor-specific immune response in humans. This is probably because DCs, which combine with Th2 in the Tim-1/Tim-4 pathway, will induce Th2 to proliferation. METHODOLOGY: We have transfected siRNA of FG-CC' gene...
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