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Article

Null genotypes at the GSTM1 and GSTT1 genes and the risk of benign prostatic hyperplasia: a case-control study and a meta-analysis.

The Prostate - 1 Jan 2013

Choubey Vimal Kumar, Sankhwar Satya Narayan, Tewari Reshu, Sankhwar Pushplata, Singh Bhupendra Pal, Rajender Singh

Abstract excerpt

BACKGROUND: Benign prostatic hyperplasia (BPH) is an age related non-malignant disease diagnosed as lower urinary tract symptoms and prostatic enlargement. Null genotypes in drug detoxification glutathione-S-transferase genes/enzymes, such as GSTT1 and GSTM1 have been reported to increase risk of several cancers including prostate. Meta-analysis on PC also suggested significant impact of GSTM1 null genotype but...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22692893
DOI: 10.1002/pros.22549

Genes

GSTM1
GSTT1

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