Article
Is colorectal surveillance indicated in patients with PTEN mutations?
Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland - 1 Sept 2012
Nieuwenhuis M H, Kets C M, Murphy-Ryan M, Colas C, Möller P, Hes F J, Hodgson S V, Olderode-Berends M J W, Aretz S, Heinimann K, Gomez Garcia E B, Douglas F, Spigelman A, Timshel S, Lindor N M, Vasen H F A
Abstract excerpt
AIM: Patients with germline phosphatase and tensin homologue (PTEN) mutations develop hamartomatous lesions in several organs and are at increased risk of various malignancies. We assessed the lifetime risk of benign and malignant gastrointestinal lesions in patients with a proven PTEN mutation. METHOD: Data on gender, mutation, dates of birth, last contact, and diagnosis, location and type of gastrointestinal...
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