Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

IPLEX administration improves motor neuron survival and ameliorates motor functions in a severe mouse model of spinal muscular atrophy.

Molecular medicine (Cambridge, Mass.) - 25 Sept 2012

Murdocca Michela, Malgieri Arianna, Luchetti Andrea, Saieva Luciano, Dobrowolny Gabriella, de Leonibus Elvira, Filareto Antonio, Quitadamo Maria Chiara, Novelli Giuseppe, Musarò Antonio, Sangiuolo Federica

Abstract excerpt

Spinal muscular atrophy (SMA) is an inherited neurodegenerative disorder and the first genetic cause of death in childhood. SMA is caused by low levels of survival motor neuron (SMN) protein that induce selective loss of α-motor neurons (MNs) in the spinal cord, resulting in progressive muscle at...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Insulin-Like Growth Factor Binding Protein 3
Share to Insulin-Like Growth Factor I

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Motor Activity

Share to Motor Neurons

Share to Muscles

Share to Muscular Atrophy, Spinal

Share to Nerve Degeneration

Share to Survival of Motor Neuron 2 Protein

Source

Open in PubMed Open full text

Identifiers

PMID: 22669476
DOI: 10.2119/molmed.2012.00056
PMCID: PMC3474434

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22669476-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

IPLEX administration improves motor neuron survival and ameliorates motor functions in a severe mouse model of spinal muscular atrophy.PMID 22669476Read ↗

IGF-1R Reduction Triggers Neuroprotective Signaling Pathways in Spinal Muscular Atrophy MiceSemantic proximity Read ↗

Molecular, genetic and stem cell-mediated therapeutic strategies for spinal muscular atrophy (SMA).Semantic proximity Read ↗

Systemic Administration of a Recombinant AAV1 Vector Encoding IGF-1 Improves Disease Manifestations in SMA MiceSemantic proximity Read ↗

Increased IGF-1 in muscle modulates the phenotype of severe SMA miceSemantic proximity Read ↗

Therapeutic benefits of cardiotrophin-1 gene transfer in a mouse model of spinal muscular atrophySemantic proximity Read ↗

Activating ATF6 in spinal muscular atrophy promotes SMN expression and motor neuron survival through the IRE1α‐XBP1 pathwaySemantic proximity Read ↗

Fasudil improves survival and promotes skeletal muscle development in a mouse model of spinal muscular atrophy.Semantic proximity Read ↗

Intravenous scAAV9 delivery of a codon-optimized SMN1 sequence rescues SMA mice.Semantic proximity Read ↗

Fetal Gene Therapy Using a Single Injection of Recombinant AAV9 Rescued SMA Phenotype in MiceSemantic proximity Read ↗

Central and peripheral delivery of AAV9-SMN target different pathomechanisms in a mouse model of spinal muscular atrophySemantic proximity Read ↗

Characterization of a murine model of SMA.Semantic proximity Read ↗

Rescue of a Mouse Model of Spinal Muscular Atrophy With Respiratory Distress Type 1 by AAV9-IGHMBP2 Is Dose Dependent.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.