Article
Combined high-resolution genotyping and geospatial analysis reveals modes of endemic urban typhoid fever transmission.
Open biology - 1 Oct 2011
Baker Stephen, Holt Kathryn E, Clements Archie C A, Karkey Abhilasha, Arjyal Amit, Boni Maciej F, Dongol Sabina, Hammond Naomi, Koirala Samir, Duy Pham Thanh, Nga Tran Vu Thieu, Campbell James I, Dolecek Christiane, Basnyat Buddha, Dougan Gordon, Farrar Jeremy J
Abstract excerpt
Typhoid is a systemic infection caused by Salmonella Typhi and Salmonella Paratyphi A, human-restricted bacteria that are transmitted faeco-orally. Salmonella Typhi and S. Paratyphi A are clonal, and their limited genetic diversity has precluded the identification of long-term transmission networks in areas with a high disease burden. To improve our understanding of typhoid transmission we have taken a novel...
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