Article
Progress towards mechanism-based treatment for Diamond-Blackfan anemia.
TheScientificWorldJournal - 1 Jan 2012
Sjögren Sara E, Flygare Johan
Abstract excerpt
Diamond-Blackfan anemia (DBA) is a congenital erythroid hypoplastic anemia, characterized by macrocytic anemia, reticulocytopenia, and severely reduced numbers of erythroid precursors in the bone marrow. For more than fifty years, glucocorticoids have remained the main option for pharmacological treatment of DBA. While continuous glucocorticoid administration increases hemoglobin levels in a majority of DBA...
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