Article
Collagen adhesin-nanoparticle interaction impairs adhesin's ligand binding mechanism.
Biochimica et biophysica acta - 1 Jul 2012
Devi Aribam Swarmistha, Ogawa Yohsuke, Shimoji Yoshihiro, Balakumar Subramanian, Ponnuraj Karthe
Abstract excerpt
BACKGROUND: Pathogenic bacteria specifically recognize extracellular matrix (ECM) molecules of the host (e.g. collagen, fibrinogen and fibronectin) through their surface proteins known as MSCRAMMs (Microbial Surface Components Recognizing Adhesive Matrix Molecules) and initiate colonization. On implantation, biomaterials easily get coated with these ECM molecules and the MSCRAMMs mediate bacterial adherence to...
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