Article
KRAS mutation and NF-κB activation indicates tolerance of chemotherapy and poor prognosis in colorectal cancer.
Digestive diseases and sciences - 1 Sept 2012
Lin Gen, Zheng Xiong-Wei, Li Chao, Chen Qiang, Ye Yun-Bin
Abstract excerpt
BACKGROUND: Evidence shows a strong relationship between KRAS mutations and the NF-κB signaling pathway. In colorectal cancer, however, the study of this subject has been very limited and results are inconsistent. AIMS: To examine the relationship between KRAS mutations and NF-κB activation and their effect on chemotherapy response and survival of colorectal cancer patients. MATERIALS AND METHODS: NF-κB...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.