Muckle-Wells syndrome and male hypofertility: a case series.

Abstract excerpt

OBJECTIVES: Muckle-Wells syndrome (MWS) is a rare autoinflammatory disorder associated with NLRP3 gene mutations, which cause excessive caspase-1 activation and processing of interleukin (IL)-1β and IL-18. Here we investigated whether MWS disease may be associated with impaired fertility in male patients. METHODS: Medical records of all male MWS patients with NLRP3 mutations followed in our tertiary center for...

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