Article
Cancer incidence in patients with polyglutamine diseases: a population-based study in Sweden.
The Lancet. Oncology - 1 Jun 2012
Ji Jianguang, Sundquist Kristina, Sundquist Jan
Abstract excerpt
BACKGROUND: Polyglutamine (polyQ) diseases are characterised by the expansion of CAG triplet repeats in specific genes. The accumulated encoded proteins affect the transcription of numerous transcription factors. We investigated whether polyQ diseases reduce the risk of cancer development. METHODS: Data on patients with the polyQ diseases Huntington's disease (HD), spinobulbar muscular atrophy (SBMA), and...
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