Article
A low-grade ovarian carcinoma case with coincident LOH of PTCH1 and BRCA1, and a mutation in BRCA1.
International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists - 1 May 2012
Maurac Ivana, Sabol Maja, Musani Vesna, Car Diana, Ozretic Petar, Kalafatic Drzislav, Oreskovic Slavko, Babic Damir, Levanat Sonja
Abstract excerpt
We report a case of a 53-year-old woman with Grade 1 serous cystadenocarcinoma on her left ovary and metastatic serous adenocarcinoma on her right ovary. Serous carcinoma is the most common type of ovarian cancer, representing approximately half of all cases. Because of positive family history, the patient was referred for BRCA1/2 screening. Germline BRCA1 mutation c.676delT (p.C226VfsX8) was found, and in tumor...
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