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Article

Perinatal gene-gene and gene-environment interactions on IgE production and asthma development.

Clinical & developmental immunology - 1 Jan 2012

Chang Jen-Chieh, Wang Lin, Chen Rong-Fu, Liu Chieh-An

Abstract excerpt

Atopic asthma is a complex disease associated with IgE-mediated immune reactions. Numerous genome-wide studies identified more than 100 genes in 22 chromosomes associated with atopic asthma, and different genetic backgrounds in different environments could modulate susceptibility to atopic asthma. Current knowledge emphasizes the effect of tobacco smoke on the development of childhood asthma. This suggests that...

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Share to Environment
Share to Epistasis, Genetic
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Developmental

Share to Genome, Human

Share to Hypersensitivity, Immediate

Share to Immunoglobulin E

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Identifiers

PMID: 22481967
DOI: 10.1155/2012/270869
PMCID: PMC3299317

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