Low-grade inflammation and the phenotypic expression of myocardial fibrosis in hypertrophic cardiomyopathy.

doi:10.1136/heartjnl-2011-300960

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Article

Low-grade inflammation and the phenotypic expression of myocardial fibrosis in hypertrophic cardiomyopathy.

Heart (British Cardiac Society) - 1 Jul 2012

Kuusisto Johanna, Kärjä Vesa, Sipola Petri, Kholová Ivana, Peuhkurinen Keijo, Jääskeläinen Pertti, Naukkarinen Anita, Ylä-Herttuala Seppo, Punnonen Kari, Laakso Markku

Abstract excerpt

OBJECTIVE: To investigate the role of inflammation in the phenotypic expression of myocardial fibrosis in hypertrophic cardiomyopathy (HCM). DESIGN: Clinical study. SETTING: Kuopio University Hospital and University of Eastern Finland, Kuopio, Finland. SUBJECTS: Twenty-four patients with a single HCM-causing mutation D175N in the α-tropomyosin gene and 17 control subjects. MAIN OUTCOME MEASURES: Endomyocardial...

Topics

Adolescent
Adult
Aged
Biopsy
Cardiomyopathy, Hypertrophic
Coronary Angiography
DNA
Echocardiography
Electrocardiography
Female
Fibrosis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Immunohistochemistry

Inflammation

Magnetic Resonance Imaging, Cine

Male

Middle Aged

Mutation

Source

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Identifiers

PMID: 22447464
DOI: 10.1136/heartjnl-2011-300960
PMCID: PMC3368494

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