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The role of telomere trimming in normal telomere length dynamics

1 Apr 2012

Abstract excerpt

Telomeres consist of repetitive DNA and associated proteins that protect chromosome ends from illicit DNA repair. It is well known that telomeric DNA is progressively eroded during cell division, until telomeres become too short and the cell stops dividing. There is a second mode of telomere shortening, however, which is a regulated form of telomere rapid deletion (TRD) termed telomere trimming that is reviewed...

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PMID: 22421147
DOI: 10.4161/cc.19632

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