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Article

Inhibition of colony-spreading activity of Staphylococcus aureus by secretion of δ-hemolysin.

The Journal of biological chemistry - 4 May 2012

Omae Yosuke, Sekimizu Kazuhisa, Kaito Chikara

Abstract excerpt

Staphylococcus aureus spreads on the surface of soft agar, a phenomenon we termed "colony spreading." Here, we found that S. aureus culture supernatant inhibited colony spreading. We purified δ-hemolysin (Hld, δ-toxin), a major protein secreted from S. aureus, as a compound that inhibits colony spreading. The culture supernatants of hld-disrupted mutants had 30-fold lower colony-spreading inhibitory activity than...

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Share to Amino Acid Sequence
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Dose-Response Relationship, Drug

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Identifiers

PMID: 22411996
DOI: 10.1074/jbc.M112.357848
PMCID: PMC3346143

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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