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Article

Multiple Pregnancy Failures: An Immunological Paradigm

1 Mar 2012

Abstract excerpt

Recurrent spontaneous abortion (RSA), three or more pregnancy losses prior to 20 weeks, occurs in about 1% of all pregnancies, 50% of RSA cases remain unexplained and unresolved. Recently, immune pathways have been implicated in the pathophysiology of RSA. Immune tolerance of the fetal-placental unit and placental angiogenesis are mandatory for a successful pregnancy outcome. Unscheduled dysregulation of the...

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PMID: 22380628
DOI: 10.1111/j.1600-0897.2012.01121.x

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