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Article

Diet-induced paternal obesity in the absence of diabetes diminishes the reproductive health of two subsequent generations of mice

21 Feb 2012

Abstract excerpt

BACKGROUND: Obesity and related conditions, notably subfertility, are increasingly prevalent. Paternal influences are known to influence offspring health outcome, but the impact of paternal obesity and subfertility on the reproductive health of subsequent generations has been overlooked. METHODS: A high-fat diet (HFD) was used to induce obesity but not diabetes in male C57Bl6 mice, which were subsequently mated...

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PMID: 22357767
DOI: 10.1093/humrep/des030

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