Article
Association study of AGER gene polymorphism and hypertension in Han Chinese population.
Gene - 1 May 2012
Yang Song, Wang Hairu, Yang Yichun, Wang Wen, Jiang Jiandong, Zhao Xianghai, Du Qinglian, Wang Xuecai, Yao Yingshui, Shen Hongbing, Shen Chong, Zhao Yanping
Abstract excerpt
BACKGROUND: Advanced glycation end products (AGEs) are produced by non-enzymatic glycation or glycoxidation of proteins, lipids and nucleic acids. The bond of AGEs and the receptor of AGE (AGER) in a pro-oxidant environment could induce immune and inflammation reaction involved in progress of microvascular disease. Accumulated evidence warrant further study on AGE-AGER pathway and genetic susceptibility to...
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