Article
An abnormal splice donor site in one allele of the thyroid peroxidase gene in FRTL5 rat thyroid cells introduces a premature stop codon: association with the absence of functional enzymatic activity.
Molecular endocrinology (Baltimore, Md.) - 1 Jun 1990
Derwahl M, Seto P, Rapoport B
Abstract excerpt
Low stringency screening of an FRTL5 cDNA library with a human thyroid peroxidase (TPO) cDNA probe yielded two different types of TPO cDNA clones. One type contained the full-length structural gene, but there was an A at the first nucleotide of an intronic splice donor site that leads to alternat...
Topics
- Alleles
- Animals
- Base Sequence
- Cell Line
- Codon
- Cricetinae
- Cricetulus
- DNA, Recombinant
- Female
- Gene Expression Regulation
- Genes
- Iodide Peroxidase
- Molecular Sequence Data
- Mutation
- Ovary
- RNA, Messenger
- Rats
- Rats, Inbred Strains