Article
Genetics of Mammalian Reproduction: Modeling the End of the Germline
2 Mar 2011
Abstract excerpt
Our understanding of reproduction and early embryonic development has directly enabled our manipulation of the mouse genome for tests of gene function in vivo. In this review, we reflect on the 30 years of work that followed this singular accomplishment. We profile murine models that have given us memorable insights into fundamental processes of male and female gametogenesis and the earliest phases of embryonic...