Article
Emerged HA and NA mutants of the pandemic influenza H1N1 viruses with increasing epidemiological significance in Taipei and Kaohsiung, Taiwan, 2009-10.
PloS one - 1 Jan 2012
Kao Chuan-Liang, Chan Ta-Chien, Tsai Chu-Han, Chu Kuan-Ying, Chuang Shu-Fang, Lee Chang-Chun, Li Zheng-Rong Tiger, Wu Ko-Wen, Chang Luan-Yin, Shen Yea-Huei, Huang Li-Min, Lee Ping-Ing, Yang Chinglai, Compans Richard, Rouse Barry T, King Chwan-Chuen
Abstract excerpt
The 2009 influenza pandemic provided an opportunity to observe dynamic changes of the hemagglutinin (HA) and neuraminidase (NA) of pH1N1 strains that spread in two metropolitan areas--Taipei and Kaohsiung. We observed cumulative increases of amino acid substitutions of both HA and NA that were higher in the post-peak than in the pre-peak period of the epidemic. About 14.94% and 3.44% of 174 isolates had one and...
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