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Article

Enhanced apoptosis and tumor growth suppression elicited by combination of MEK (selumetinib) and mTOR kinase inhibitors (AZD8055).

Cancer research - 1 Apr 2012

Holt Sarah V, Logie Armelle, Davies Barry R, Alferez Denis, Runswick Sarah, Fenton Sarah, Chresta Christine M, Gu Yi, Zhang Jingchuan, Wu Yi-Long, Wilkinson Robert W, Guichard Sylvie M, Smith Paul D

Abstract excerpt

The mitogen-activated protein kinase (MAPK) and phosphoinositide 3-kinase/AKT signaling pathways interact at multiple nodes in cancer, including at mTOR complexes, suggesting an increased likelihood of redundancy and innate resistance to any therapeutic effects of single pathway inhibition. In this study, we investigated the therapeutic effects of combining the MAPK extracellular signal-regulated kinase (MEK)1/2...

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Identifiers

PMID: 22271687
DOI: 10.1158/0008-5472.CAN-11-1780

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DUSP6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Enhanced apoptosis and tumor growth suppression elicited by combination of MEK (selumetinib) and mTOR kinase inhibitors (AZD8055).PMID 22271687Read ↗

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