Article
Pharmacogenetics of drugs withdrawn from the market.
Pharmacogenomics - 1 Jan 2012
Zhang Wei, Roederer Mary W, Chen Wang-Qing, Fan Lan, Zhou Hong-Hao
Abstract excerpt
The safety and efficacy of candidate compounds are critical factors during the development of drugs, and most drugs have been withdrawn from the market owing to severe adverse reactions. Individuals/populations with different genetic backgrounds may show significant differences in drug metabolism and efficacy, which can sometimes manifest as severe adverse drug reactions. With an emphasis on the mechanisms...
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