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Article

A dynamical model of oocyte maturation unveils precisely orchestrated meiotic decisions.

PLoS computational biology - 1 Jan 2012

Pfeuty Benjamin, Bodart Jean-Francois, Blossey Ralf, Lefranc Marc

Abstract excerpt

Maturation of vertebrate oocytes into haploid gametes relies on two consecutive meioses without intervening DNA replication. The temporal sequence of cellular transitions driving eggs from G2 arrest to meiosis I (MI) and then to meiosis II (MII) is controlled by the interplay between cyclin-dependent and mitogen-activated protein kinases. In this paper, we propose a dynamical model of the molecular network that...

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Identifiers

PMID: 22238511
DOI: 10.1371/journal.pcbi.1002329
PMCID: PMC3252271

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