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Article

Mechanisms of resistance to crizotinib in patients with ALK gene rearranged non-small cell lung cancer.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Mar 2012

Doebele Robert C, Pilling Amanda B, Aisner Dara L, Kutateladze Tatiana G, Le Anh T, Weickhardt Andrew J, Kondo Kimi L, Linderman Derek J, Heasley Lynn E, Franklin Wilbur A, Varella-Garcia Marileila, Camidge D Ross

Abstract excerpt

PURPOSE: Patients with anaplastic lymphoma kinase (ALK) gene rearrangements often manifest dramatic responses to crizotinib, a small-molecule ALK inhibitor. Unfortunately, not every patient responds and acquired drug resistance inevitably develops in those who do respond. This study aimed to define molecular mechanisms of resistance to crizotinib in patients with ALK(+) non-small cell lung cancer (NSCLC)....

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Source

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Identifiers

PMID: 22235099
DOI: 10.1158/1078-0432.CCR-11-2906
PMCID: PMC3311875

Genes

ALK
EGFR
KRAS

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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