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Article

Efficient Blockade of Akt signaling is a determinant factor to overcome resistance to Matuzumab

1 Dec 2011

Abstract excerpt

BACKGROUND: Clinical studies have shown antineoplastic effectiveness of monoclonal antibodies (MAbs) against EGFR for different indications. Several MAbs directed to EGFR were developed recently, such as matuzumab, but there is still lack of information on preclinical data on its combination with chemo-radiation. Thus, the present study intended to examine the molecular pathways triggered by matuzumab alone or...

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PMID: 22185378
DOI: 10.1186/1476-4598-10-151

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