Article
Aged vervet monkeys developing transthyretin amyloidosis with the human disease-causing Ile122 allele: a valid pathological model of the human disease.
Laboratory investigation; a journal of technical methods and pathology - 1 Mar 2012
Ueda Mitsuharu, Ageyama Naohide, Nakamura Shinichiro, Nakamura Minami, Chambers James Kenn, Misumi Yohei, Mizuguchi Mineyuki, Shinriki Satoru, Kawahara Satomi, Tasaki Masayoshi, Jono Hirofumi, Obayashi Konen, Sasaki Erika, Une Yumi, Ando Yukio
Abstract excerpt
Mutant forms of transthyretin (TTR) cause the most common type of autosomal-dominant hereditary systemic amyloidosis. In addition, wild-type TTR causes senile systemic amyloidosis, a sporadic disease seen in the elderly. Although spontaneous development of TTR amyloidosis had not been reported in animals other than humans, we recently determined that two aged vervet monkeys (Chlorocebus pygerythrus) spontaneously...
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