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Article

Hormesis does not make sense except in the light of TOR-driven aging

12 Dec 2011

Abstract excerpt

Weak stresses (including weak oxidative stress, cytostatic agents, heat shock, hypoxia, calorie restriction) may extend lifespan. Known as hormesis, this is the most controversial notion in gerontology. For one, it is believed that aging is caused by accumulation of molecular damage. If so, hormetic stresses (by causing damage) must shorten lifespan. To solve the paradox, it was suggested that, by activating...

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PMID: 22166724
DOI: 10.18632/aging.100411

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