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New understandings of the genetic basis of isolated idiopathic central hypogonadism

5 Dec 2011

Abstract excerpt

Idiopathic hypogonadotropic hypogonadism is a rare disease that is characterized by delayed/absent puberty and/or infertility due to an insufficient stimulation of an otherwise normal pituitary-gonadal axis by gonadotrophin-releasing hormone (GnRH) action. Because reduced or normal luteinizing hormone (LH)/follicle-stimulating hormone (FSH) levels may be observed in the affected patients, the term idiopathic...

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PMID: 22138902
DOI: 10.1038/aja.2011.68

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