Article
Selective radiosensitization of p53 mutant pancreatic cancer cells by combined inhibition of Chk1 and PARP1.
Cell cycle (Georgetown, Tex.) - 15 Dec 2011
Vance Sean, Liu Erqi, Zhao Lili, Parsels Joshua D, Parsels Leslie A, Brown Jeffery L, Maybaum Jonathan, Lawrence Theodore S, Morgan Meredith A
Abstract excerpt
We have recently shown that inhibition of HRR (homologous recombination repair) by Chk1 (checkpoint kinase 1) inhibition radiosensitizes pancreatic cancer cells and others have demonstrated that Chk1 inhibition selectively sensitizes p53 mutant tumor cells. Furthermore, PARP1 [poly (ADP-ribose) polymerase-1] inhibitors dramatically radiosensitize cells with DNA double strand break repair defects. Thus, we...
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